Table of Contents
Introduction to FT4 Chemiluminescence Test
The Free Thyroxine (FT4) chemiluminescence test measures the level of free thyroxine in the blood. Free thyroxine is an unbound hormone, which is crucial in evaluating thyroid function. The test is widely used to diagnose thyroid disorders such as hyperthyroidism and hypothyroidism.
Purpose of the FT4 Chemiluminescence Test
The FT4 chemiluminescence test provides an accurate measure of the biologically active fraction of thyroxine. It is instrumental in diagnosing and managing thyroid conditions. Normal levels of free T4 typically range from 0.7 to 1.9 ng/dL. Deviations from these values may indicate potential thyroid dysfunction.
Chemiluminescence Assay Methodology
The chemiluminescence assay utilizes a luminous chemical reaction to detect the presence and quantity of free T4 in a blood sample. The methodology involves binding of T4 to specific antibodies that are tagged with a chemiluminescent marker. Upon exposure to a triggering reagent, the marker emits light, which is measured using a luminometer.
Company Solutions for FT4 Testing
- Roche Diagnostics: Provides the Elecsys FT4 II immunoassay, known for its precision and short turnaround time.
- Abbott Laboratories: Offers the ARCHITECT Free T4 assay, emphasizing high sensitivity and specificity in thyroid function testing.
- Siemens Healthineers: Their ADVIA Centaur FT4 assay is renowned for its reproducibility and reliability.
Conclusion
The FT4 chemiluminescence test remains a critical component in the diagnostic toolkit for thyroid-related conditions. Advances in assay technologies continue to improve the accuracy and efficiency of these tests, thereby enhancing patient care and treatment outcomes.
References
- Roche Diagnostics. (2023). Elecsys FT4 II Immunoassay.
- Abbott Laboratories. (2023). ARCHITECT Free T4 Assay.
- Siemens Healthineers. (2023). ADVIA Centaur FT4 Assay.
- Smith, J., & Johnson, L. (2021). Clinical Thyroidology for the Clinician. Journal of Thyroid Research, 15(3), 45-60.